GenovaTM Pseudouridine-5'-Triphosphate

Cat#

MRNA-4504

CAS#: 

1175-34-4

Molecular Formula

C9H15N2O15P3

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GenovaTM Pseudouridine-5'-Triphosphate

GenovaTM Pseudouridine-5'-Triphosphate

Cat#

MRNA-4504

CAS#: 

1175-34-4

Synonyms

Pseudouridine-5'-triphosphate

[[(2R,3S,4R,5S)-5-(2,4-dioxo-1H-pyrimidin-5-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]phosphono hydrogen phosphate

1175-34-4

SCHEMBL625518

ZINC77312680

Pseudouridine5'-Triphosphate Triethylamine Salt

J-003632

W-200908

Pseudouridine5'-Triphosphate Triethylamine Salt, >85per cent

((2R,3S,4R,5S)-5-(2,4-Dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyltetrahydrogen triphosphate

Molecular Formula

C9H15N2O15P3

Molecular Weight

484.14

Storage Temp.

−20°C

Background

Pseudouridine (5-ribosyluracil)was the first modified ribonucleoside discovered. It is the most abundantnatural modified RNA base, and has been deemed the "fifth nucleoside"in RNA. It can be found in structural RNAs, such as transfer, ribosomal andsmall nuclear RNA. Pseudouridine has been found to enhance base stacking andtranslation. Pseudouridine-5'-triphosphate (Pseudo-UTP) is used to impartdesirable mRNA characteristics such as increased nuclease stability, increasedtranslation or altered interaction of innate immune receptors with in vitrotranscribed RNA. 

Pseudo-UTP, also known aspseudouridine-5’-O-triphosphate, is one of the most commonly usedmodified nucleoside-5’-O-triphosphates. Pseudo-UTP is a building blockfor the polymerase-mediated synthesis of RNA molecules. RNA molecules,especially messenger RNAs (mRNAs), have widespread applications in therapeuticand diagnostic areas, and have demonstrated their superiority over plasmid DNAtechniques in both gene and vaccination therapy. Compared with uridine-containingunmodified mRNAs, the application of pseudouridine-containing modified mRNAsexhibits better nuclease stability, immunogenicity, and translationalproperties. Thus, pseudo-UTP could be used to develop drugable mRNAs withimproved properties, by replacing the standard bases by modified ones. 

GenovaTM Pseudouridine-5'-Triphosphate

Cat#

MRNA-4504

CAS#: 

1175-34-4

Synonyms

Pseudouridine-5'-triphosphate

[[(2R,3S,4R,5S)-5-(2,4-dioxo-1H-pyrimidin-5-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]phosphono hydrogen phosphate

1175-34-4

SCHEMBL625518

ZINC77312680

Pseudouridine5'-Triphosphate Triethylamine Salt

J-003632

W-200908

Pseudouridine5'-Triphosphate Triethylamine Salt, >85per cent

((2R,3S,4R,5S)-5-(2,4-Dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyltetrahydrogen triphosphate

Molecular Formula

C9H15N2O15P3

Molecular Weight

484.14

Storage Temp.

−20°C

Background

Pseudouridine (5-ribosyluracil)was the first modified ribonucleoside discovered. It is the most abundantnatural modified RNA base, and has been deemed the "fifth nucleoside"in RNA. It can be found in structural RNAs, such as transfer, ribosomal andsmall nuclear RNA. Pseudouridine has been found to enhance base stacking andtranslation. Pseudouridine-5'-triphosphate (Pseudo-UTP) is used to impartdesirable mRNA characteristics such as increased nuclease stability, increasedtranslation or altered interaction of innate immune receptors with in vitrotranscribed RNA. 

Pseudo-UTP, also known aspseudouridine-5’-O-triphosphate, is one of the most commonly usedmodified nucleoside-5’-O-triphosphates. Pseudo-UTP is a building blockfor the polymerase-mediated synthesis of RNA molecules. RNA molecules,especially messenger RNAs (mRNAs), have widespread applications in therapeuticand diagnostic areas, and have demonstrated their superiority over plasmid DNAtechniques in both gene and vaccination therapy. Compared with uridine-containingunmodified mRNAs, the application of pseudouridine-containing modified mRNAsexhibits better nuclease stability, immunogenicity, and translationalproperties. Thus, pseudo-UTP could be used to develop drugable mRNAs withimproved properties, by replacing the standard bases by modified ones.