GenovaTM 5-Methoxy-Uridine 5'-Triphosphate

Cat#

MRNA-4502

Molecular Formula

C10H14N2Na3O16P3

Molecular Weight

514.1

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GenovaTM 5-Methoxy-Uridine 5'-Triphosphate

GenovaTM 5-Methoxy-Uridine5'-Triphosphate

Cat#

MRNA-4502

Synonyms
5-Methoxyuridine 5'-triphosphate

847649-65-4

SCHEMBL21277423

Molecular Formula

C10H14N2Na3O16P3

Molecular Weight

514.1

Storage Temp.

−20°C

Background

5-Methoxy-UTP is ananalogue of the naturally occurring uridine triphosphate (UTP). Similar toN1-methylpseudouridine and pseudouridine modifications, 5-methoxyuridine isanother common chemical modification used for in vitro mRNAsynthesis in order to improve mRNA activity and reduce innate immune responses.Chemical modifications of mRNAs with 5-methoxyuridine, N1-methylpseudouridineand pseudouridine have been shown to significantly improve the expression ofenhanced green fluorescent protein (eGFP) in a variety of cell lines, amongwhich 5-methoxyuridine-modified eGFP mRNA is more stable than other eGFP mRNAs.In addition, replacing UTP with 5-methoxy-UTP in Cas9 mRNA hasalso been reported to reduce innate immune responses, making the broad use ofCas9 possible both in vitro and in vivo

GenovaTM 5-Methoxy-Uridine5'-Triphosphate

Cat#

MRNA-4502

Synonyms
5-Methoxyuridine 5'-triphosphate

847649-65-4

SCHEMBL21277423

Molecular Formula

C10H14N2Na3O16P3

Molecular Weight

514.1

Storage Temp.

−20°C

Background

5-Methoxy-UTP is ananalogue of the naturally occurring uridine triphosphate (UTP). Similar toN1-methylpseudouridine and pseudouridine modifications, 5-methoxyuridine isanother common chemical modification used for in vitro mRNAsynthesis in order to improve mRNA activity and reduce innate immune responses.Chemical modifications of mRNAs with 5-methoxyuridine, N1-methylpseudouridineand pseudouridine have been shown to significantly improve the expression ofenhanced green fluorescent protein (eGFP) in a variety of cell lines, amongwhich 5-methoxyuridine-modified eGFP mRNA is more stable than other eGFP mRNAs.In addition, replacing UTP with 5-methoxy-UTP in Cas9 mRNA hasalso been reported to reduce innate immune responses, making the broad use ofCas9 possible both in vitro and in vivo